発表論文｜月田研究室（帝京大学先端総合研究機構）

発表論文

#：corresponding author

2024
Shiratsuchi G, Konishi S, Yano T, Yanagihashi Y, Nakayama S, Katsuno T, Kashihara H, Tanaka H, Tsukita K, Suzuki K, Herawati E, Watanabe H, Hirai T, Yagi T, Kondoh G, Gotoh S, ^#Tamura A, and ^#Tsukita S. 2024. Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons. EMBO Rep. 25:1176-1207. https://doi.org/10.1038/s44319-024-00066-0
Oami T, Abtahi S, Shimazui T, Chen CW, Sweat YY, Liang Z, Burd EM, Farris AB, Roland JT, Tsukita S, Ford ML, ^#Turner JR, and ^#Coopersmith CM. 2024. Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis. Proc Natl Acad Sci U S A. 121(10): e2217877121. https://doi.org/10.1073/pnas.2217877121
^#Citi S, Fromm M, Furuse M, Gonzalez-Mariscal L, Nusrat A, Tsukita S, and Turner JR. 2024. A short guide to the tight junction. J Cell Sci. 137(9): jcs261776. https://doi.org/10.1242/jcs.261776
Ito Y, Marouf A, ---------- (37名) ---------- Tsukita S, --- (9名) --- ^#Kataoka K and ^#Couronne L. 2024. Comprehensive genetic profiling reveals frequent alterations of driver genes on the X chromosome in extranodal NK/T-cell lymphoma. Cancer Res. 2024 Apr 24. https://doi.org/10.1158/0008-5472.CAN-24-0132
2023
Tsukita,K., Kitamata,M., Kashihara,H., Yano,T., Fujiwara,I., F Day,T., Katsuno,T., Kim,J., Takenaga,F., Tanaka,H., Park,S., Miyata,M., Watanabe,H., Kondoh,G., Takahashi,R., ^#Tamura,A., and ^#Tsukita,S. 2023. Phase separation of an acitn nucleator by junctional microtubules regulates epithelial function. Science Adv. 9: eadf6358. https://doi.org/10.1126/sciadv.adf6358
Eisenstein, F., Yanagisawa, H., Kashihara, H., Kikkawa, M., Tsukita, S., and ^#Danev, R. 2023.Parallel cryo electron tomography on in situ lamellae. Nature Methods 20:130-138. https://doi.org/10.1038/s41592-022-01690-1
Suzuki,K., Yamaga,K., Tokumasu,R., Katsuno,T., Tanaka,H., Chiba,S., Yagi,T., Katayama,I., Tamura,A., Murota,H., and ^#Tsukita,S. 2023.Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice. Ann NY Acad Sci. 1523:51-61. https://doi.org/10.1111/nyas.14980
Sugiyama, S., ^#Sasaki, T., Tanaka, H., Yan, H., Ikegami, T., Kanki, H., Nishiyama, K., Beck, G., Gon, Y., Okazaki, S., Todo, K., Tamura, A., Tsukita, S., and Mochizuki,H. 2023.The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.Sci Rep. 18;13:2892. https://doi.org/10.1038/s41598-023-29894-1
2021
Ozono, Y., ^#Tamura, A., Nakayama, S., Herawati, E., Hanada, Y., Ohata, K., Takagishi, M., Takahashi, M., Imai, T., Ohta, Y., Oshima, K., Sato, T., Inohara, H., and ^#Tsukita, S. 2021. Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules. Sci Rep. 11(1):20224. https://doi.org/10.1038/s41598-021-96232-8
^#Kim, J., Tamura, A., Tsukita, S., and ^#Parl, S. 2021. Uniaxial stretching device for studying maturity-dependent morphological response of epithelial cell monolayers to tensile strain. J Ind Eng Chem. 99: 282- 291. https://doi.org/10.1016/j.jiec.2021.04.036
Sone, N., Konishi, S., Igura, K., Tamai, K., Ikeo, S., Korogi, Y., Kanagaki, S., Namba, T., Yamamoto, Y., Xu, Y., Takeuchi, K., Adachi, Y., Chen-Yoshikawa, T.F., Date, H., Hagiwara, M., Tsukita, S., Hirai, T., Torisawa, Y., and ^#Goto, S. 2021. Multicellular Modeling of Ciliopathy by Combining iPS cells and Microfluidic Airway-on-a chip Technology. Sci Transl Med. 13(601):eabb1298. https://doi.org/10.1126/scitranslmed.abb1298
^#Sato, K., Matsumoto, I., Suzuki, K., Kasamatsu, J., Yamamoto, H., Miyasaka, T., Miyahara, A., Zong, T., Kagesawa, T., Oniyama, A., Kawamura, K., Kitai, Y., Umeki, A., Kannno, E., Tanno, H., Ishii, K., Tsukita, S., and Kawakami, K. 2021. Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs. Sci Rep. 11(1):21110. https://doi.org/10.1038/s41598-021-00708-6
Nakayama, S., Yano, T., Namba, T., Konishi, S., Takagishi, M., Herawati, E., Nishida, T., Imoto, Y., Ishihara, S., Takahashi, M., Furuta, K., Oiwa, K., Tamura, A., and ^#Tsukita, S. 2021. Planar cell polarity induces local microtubule bundling for coordinated ciliary beating. J Cell Biol. 220(7):e202010034. https://doi.org/10.1083/jcb.202010034
Yano, T., Tsukita, K., Kanoh, H., Nakayama, S., Kashihara, H., Mizuno, T., Tanaka, H., Matsui, T., Goto, Y., Komatsubara, A., Aoki, K., Takahashi, R., ^#Tamura, A., and ^#Tsukita, S. 2021. A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction. EMBO J. 40(2):e104712. https://doi.org/10.15252/embj.2020104712
2020
Matsuo, J., Douchi, D., Myint, K., Mon, NN., Yamamura, A., Kohu, K., Heng, DL., Chen, S., Mawan, NA., Nuttonmanit, N., L,i Y., Srivastava, S., Ho, SWT., Lee, NYS., Lee, HK., Adachi, M., Tamura, A., Chen, J., Yang, H., Teh, M., So, JB., Yong, WP., Tan, P., Yeoh, KG., ^#Chuang, LSH., ^#Tsukita, S., and ^#Ito, Y. 2020. Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. Gut. gutjnl-2020-322779. https://doi.org/10.1136/gutjnl-2020-322779
Raju, P., Shashikanth, N., Tsai, PY., Pongkorpsakol, P., Chanez-Parades, S., Steinhagen, PR., Kuo, WT., Singh, G., Tsukita, S., and ^#Turner, JR. 2020. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. J Clin Invest. 130(10):5197-5208. https://doi.org/10.1172/JCI138697
2019
^#Tsukita, S., Tanaka, H., and Tamura, A. 2019. The Claudins: From Tight Junctions to Biological Systems. Trends Biochem Sci. 44(2):141-152. https://doi.org/10.1016/j.tibs.2018.09.008
Nakamura, S., Irie, K., Tanaka, H., Nishikawa, K., Suzuki, H., Saitoh, Y., Tamura, A., Tsukita, S., and ^#Fujiyoshi, Y. 2019. Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun. 10(1):816. https://doi.org/10.1038/s41467-019-08760-7
Tsukita, K., Yano, T., Tamura, A., and ^#Tsukita, S. 2019. Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function? Int J Mol Sci. 20(23):6012. https://doi.org/10.3390/ijms20236012
Konishi, S., Yano, T., Tanaka, H., Mizuno, T., Kanoh, H., Tsukita, K., Namba, T., Tamura, A., Yonemura, S., Gotoh, S., Matsumoto, H., Hirai, T., and ^#Tsukita, S. 2019. Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions. Life Sci Alliance. 2(4):e201900414. https://doi.org/10.26508/lsa.201900414
Ito, C., Akutsu, H., Yao, R., Yoshida, K., Yamatoya, K., Mutoh, T., Makino, T., Aoyama, K., Ishikawa, H., Kunimoto, K., Tsukita, S., Noda, T., Kikkawa, M., and ^#Toshimori, K. 2019. Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice. Sci Rep. 9(1):14249. https://doi.org/10.1038/s41598-019-50516-2
Rouaud, F., Vasileva, E., Spadaro, D., Tsukita, S., and ^#Citi, S. 2019. R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing. Tissue Barriers. 7(3):e1653748. https://doi.org/10.1080/21688370.2019.1653748
Suzuki, K., Sentani, K., Tanaka, H., Yano, T., Suzuki, K., Oshima, M., Yasui, W., Tamura, A., and ^#Tsukita, S. 2019. Deficiency of stomach-type claudin-18 in mice induces gastric tumor formation independent of H pylori infection. Cell Mol Gastroenterol Hepatol. 8(1):119-142. https://doi.org/10.1016/j.jcmgh.2019.03.003
Zha, JM., Li, HS., Lin, Q., Kuo, WT., Jiang, ZH., Tsai, PY., Ding, N., Wu, J., Xu, SF., Wang, YT., Pan, J., Zhou, XM., Chen, K., Tao, M., Odenwald, MA., Tamura, A., Tsukita, S., ^#Turner, JR., and ^#He, WQ. 2019. Interleukin 22 expands transit-amplifying cells while depleting Lgr5(+) stem cells via Inhibition of Wnt and Notch signaling. Cell Mol Gastroenterol Hepatol. 7(2):255-274. https://doi.org/10.1016/j.jcmgh.2018.09.006
Kashihara, H., Chiba, S., Kanno, SI., Suzuki, K., Yano, T., and ^#Tsukita, S. 2019. Cep128 associates with Odf2 to form the subdistal appendage of the centriole. Genes Cells. 24(3):231-243. https://doi.org/10.1111/gtc.12668
Tsukita, S., Yano,T., and Herawati, E. 2019. Apical Cytoskeletons help define the barrier functions of epithelial cell sheets in biological systems. Make Life Visible (Springer Open) 31-38. https://doi.org/10.1007/978-981-13-7908-6_4
2018
Yano, T., Torisawa, T., Oiwa, K., and ^#Tsukita, S. 2018. AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules. Sci Rep. 8(1):15550. https://doi.org/10.1038/s41598-018-33418-7
Tanaka, H., Imasato, M., Yamazaki, Y., Matsumoto, K., Kunimoto, K., Delpierre, J., Meyer, K., Zerial, M., Kitamura, N., Watanabe, M., Tamura, A., and ^#Tsukita ,S. 2018. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. J Hepatol. 69(6):1308-1316. https://doi.org/10.1016/j.jhep.2018.08.025
Yamaga, K., Murota, H., Tamura, A., Miyata, H., Ohmi, M., Kikuta, J., Ishii, M., ^#Tsukita, S., and Katayama, I. 2018. Claudin-3 loss causes leakage of sweat from the sweat gland to contribute to the pathogenesis of atopic dermatitis. J Invest Dermatol. 138(6):1279-1287. https://doi.org/10.1016/j.jid.2017.11.040
2017
Tanaka, H., Tamura, A., Suzuki, K., and ^#Tsukita, S. 2017. Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism. Ann N Y Acad Sci. 1405(1):44-52. https://doi.org/10.1111/nyas.13438
Yano, T., Kanoh, H., Tamura, A., and ^#Tsukita, S. 2017. Apical cytoskeletons and tight junctions as a unified system in epithelial cell sheets. Ann N Y Acad Sci. 1405(1):32-43. https://doi.org/10.1111/nyas.13432
Tokumasu, R., Tamura, A., and ^#Tsukita, S. 2017. Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin. Tissue Barriers. 5(3):e1336194. https://doi.org/10.1080/21688370.2017.1336194
Tsai, P.Y., Zhang, B., He, W.Q., Zha, J.M., Odenwald, M.A., Singh, G., Tamura, A., Shen, L., Sailer, A., Yeruva, S., Kuo, W.T., Fu, Y.X., Tsukita, S., and ^#Turner, JR. 2017. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. Cell Host Microbe. 21(6):671-681.e4. https://doi.org/10.1016/j.chom.2017.05.009
^#Dunst, J., Azzouz, N., Liu, X., Tsukita, S., Seeberger, P.H., and ^#Kamena, F. 2017. Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in Malaria pathology. Front Cell Infect Microbiol. 7:183. https://doi.org/10.3389/fcimb.2017.00183
Tateishi, K., Nishida, T., Inoue, K., and ^#Tsukita, S. 2017. Three-dimensional organization of layered apical cytoskeletal networks associated with mouse airway tissue development. Sci Rep. 7:43783. https://doi.org/10.1038/srep43783
Fujimoto, K., Kinoshita, M., Tanaka, H., Okuzaki, D., Shimada, Y., Kayama, H., Okumura, R., Furuta, Y., Narazaki, M., Tamura, A., Hatakeyama, S., Ikawa, M., Tsuchiya, K., Watanabe, M., Kumanogoh, A., Tsukita, S., and ^#Takeda, K. 2017. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 10(2):446-459. https://doi.org/10.1038/mi.2016.58
Okano, T., Takeuchi, S., Soma, Y., Suzuki, K., Tsukita, S., Ishizu, A., Suzuki, K., and ^#Kawakami, T. 2017. Presence of anti-phosphatidylserine-prothrombin complex antibodies and anti-moesin antibodies in patients with polyarteritis nodosa. J Dermatol. 44(1):18-22. https://doi.org/10.1111/1346-8138.13491
2016
Herawati, E., Taniguchi, D., Kanoh, H., Tateishi, K., Ishihara, S., and ^#Tsukita, S. 2016. Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton. J Cell Biol. 214(5):571-86. https://doi.org/10.1083/jcb.201601023
Tokumasu, R., Yamaga, K., Yamazaki, Y., Murota, H., Suzuki, K., Tamura, A., Bando, K., Furuta, Y., Katayama, I., and ^#Tsukita, S. 2016. Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 113(28):E4061-8. https://doi.org/10.1073/pnas.1525474113
^#Oneyama, C., Yoshikawa, Y., Ninomiya, Y., Iino, T., Tsukita, S., and Okada, M. 2016. Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression. Oncogene. 35(4):501-12. https://doi.org/10.1038/onc.2015.110
Konishi, S., ^#Gotoh, S., Tateishi, K., Yamamoto, Y., Korogi, Y., Nagasaki, T., Matsumoto, H., Muro, S., Hirai, T., Ito, I., Tsukita, S., and Mishima, M. 2016. Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells. Stem Cell Reports. 6(1):18-25. https://doi.org/10.1016/j.stemcr.2015.11.010
Tanaka, H., Yamamoto, Y., Kashihara, H., Yamazaki, Y., Tani, K., Fujiyoshi, Y., Mineta, K., Takeuchi, K., ^#Tamura, A., and ^#Tsukita, S. 2016. Claudin-21 Has a Paracellular Channel Role at Tight Junctions. Mol Cell Biol. 36(6):954-64. https://doi.org/10.1128/MCB.00758-15