発表論文

#：corresponding author

• 2015
• Kamitani, T., Sakaguchi, H., Tamura, A., Miyashita, T., Yamazaki, Y., Tokumasu, R., Inamoto, R., Matsubara, A., Mori, N., Hisa, Y., and ^#Tsukita, S. 2015. Deletion of tricellulin causes progressive hearing loss associated with degeneration of cochlear hair cells. Sci Rep. 5:18402. https://doi.org/10.1038/srep18402
• Tanaka, H., Takechi, M., Kiyonari, H., Shioi, G., Tamura, A., and ^#Tsukita, S. 2015. Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice. Gut. 64(10):1529-38. https://doi.org/10.1136/gutjnl-2014-308419
• ^#Hatano, R., Akiyama, K., Tamura, A., Hosogi, S., Marunaka, Y., Caplan, M.J., Ueno,Y., Tsukita, S., and ^#Asano, S. 2015. Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice. Hepatology 61(5):1660-71. https://doi.org/10.1002/hep.27565
• Hausrat, T.J., Muhia, M., Gerrow, K., Thomas, P., Hirdes, W., Tsukita, S., Heisler, F.F., Herich, L., Dubroqua, S., Breiden, P., Feldon, J., Schwarz, J.R., Yee, B.K., Smart, T.G., Triller, A., and ^#Kneussel, M. 2015. Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nat Commun. 6:6872. https://doi.org/10.1038/ncomms7872
• Saitoh, Y., Suzuki, H., Tani, K., Nishikawa, K., Irie, K., Ogura, Y., Tamura, A., Tsukita, S., and ^#Fujiyoshi, Y. 2015. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science. 347(6223):775-8. https://doi.org/10.1126/science.1261833
• Liu, X., Yang, T., Suzuki, K., Tsukita, S., Ishii, M., Zhou, S., Wang, G., Cao, L., Qian, F., Taylor, S., Oh, M.J., Levitan, I., Ye, R.D., Carnegie, G.K., ^#Zhao, Y., Malik, A.B., and ^#Xu, J. 2015. Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient. J Exp Med. 212(2):267-80. https://doi.org/10.1084/jem.20140508
• Suzuki, H., Tani, K., Tamura, A., ^#Tsukita, S., and ^#Fujiyoshi, Y. 2015. Model for the architecture of claudin-based paracellular ion channels through tight junctions. J Mol Biol. 427(2):291-7. https://doi.org/10.1016/j.jmb.2014.10.020
• 2014
• Tamura, A., and ^#Tsukita, S. 2014. Paracellular barrier and channel functions of TJ claudins in organizing biological systems: advances in the field of barriology revealed in knockout mice. Semin Cell Dev Biol. 36:177-85. https://doi.org/10.1016/j.semcdb.2014.09.019
• Matsumoto, K., Imasato, M., Yamazaki, Y., Tanaka, H., Watanabe, M., Eguchi, H., Nagano, H., Hikita, H., Tatsumi, T., Takehara, T., Tamura, A., and ^#Tsukita, S. 2014. Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice. Gastroenterology. 147(5):1134-45.e10. https://doi.org/10.1053/j.gastro.2014.07.033
• Adachi, M., Kawasaki, A., Nojima, H., Nishida, E., and ^#Tsukita, S. 2014. Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis. Genes Cells. 19(11):803-20. https://doi.org/10.1111/gtc.12179
• Nishimura, T., Higuchi, K., Sai, Y., Sugita, Y., Yoshida, Y., Tomi, M., Wada, M., Wakayama, T., Tamura, A., Tsukita, S., Soga, T., and ^#Nakashima, E. 2014. Fetal growth retardation and lack of hypotaurine in ezrin knockout mice. PLoS One. 9(8):e105423. https://doi.org/10.1371/journal.pone.0105423
• Matsumoto, Y., Inden, M., Tamura, A., Hatano, R., Tsukita, S., and ^#Asano, S. 2014. Ezrin mediates neuritogenesis via down-regulation of RhoA activity in cultured cortical neurons. PLoS One. 9(8):e105435. https://doi.org/10.1371/journal.pone.0105435
• ^#Suzuki, K., Nagao, T., Itabashi, M., Hamano, Y., Sugamata, R., Yamazaki, Y., Yumura, W., Tsukita, S., Wang, P.C., Nakayama, T., and Suzuki, K. 2014. A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis. Nephrol Dial Transplant. 29(6):1168-77. https://doi.org/10.1093/ndt/gft469
• Suzuki, H., Nishizawa, T., Tani, K., Yamazaki, Y., Tamura, A., Ishitani, R., Dohmae, N., Tsukita, S., ^#Nureki, O., and ^#Fujiyoshi, Y. 2014. Crystal structure of a claudin provides insight into the architecture of tight junctions. Science. 344(6181):304-7. https://doi.org/10.1126/science.1248571
• 2013
• Yano, T., Matsui, T., Tamura, A., Uji, M., and ^#Tsukita, S. 2013. The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK. J Cell Biol. 203(4):605-14. https://doi.org/10.1083/jcb.201304194
• Tateishi, K., Yamazaki, Y., Nishida, T., Watanabe, S., Kunimoto, K., Ishikawa, H., and ^#Tsukita, S. 2013. Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains. J Cell Biol. 203(3):417-25. https://doi.org/10.1083/jcb.201303071
• Wada, M., Tamura, A., Takahashi, N., and ^#Tsukita, S. 2013. Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition. Gastroenterology. 144(2):369-80. https://doi.org/10.1053/j.gastro.2012.10.035
• Suzuki, H., Ito, Y., Yamazaki, Y., Mineta, K., Uji, M., Abe, K., Tani, K., ^#Fujiyoshi, Y., and ^#Tsukita, S. 2013. The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat. Nat Commun. 4:1766. https://doi.org/10.1038/ncomms2731
• Hayashi, H., Tamura, A., Krishnan, D., Tsukita, S., Suzuki, Y., Kocinsky, H.S., Aronson, P.S., Orlowski, J., Grinstein, S., and ^#Alexander, R.T. 2013. Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PLoS One. 8(2):e55623. https://doi.org/10.1371/journal.pone.0055623
• 2012
• Lei, Z., Maeda, T., Tamura, A., Nakamura, T., Yamazaki, Y., Shiratori, H., Yashiro, K., ^# Tsukita, S., and ^#Hamada, H. 2012. EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 371(2):136-45. https://doi.org/10.1016/j.ydbio.2012.07.005
• ^#Hirata, T., Nomachi, A., Tohya, K., Miyasaka, M., Tsukita, S., Watanabe, T., and Narumiya, S. 2012. Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. Int Immunol. 24(11):705-17. https://doi.org/10.1093/intimm/dxs077
• Tamura, A., Yamazaki, Y., Hayashi, D., Suzuki, K., Sentani, K., Yasui, W., and ^#Tsukita,S. 2012. Claudin-based paracellular proton barrier in the stomach. Ann N Y Acad Sci. 1258:108-14. https://doi.org/10.1111/j.1749-6632.2012.06570.x
• ^#Itoh, M., Tsukita, S., Yamazaki, Y., and Sugimoto, H. 2012. Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling. Proc Natl Acad Sci U S A. 109(25):9905-10. https://doi.org/10.1073/pnas.1115063109
• Hayashi, D., Tamura, A., Tanaka, H., Yamazaki, Y., Watanabe, S., Suzuki, K., Suzuki, K., Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and ^#Tsukita, S. 2012. Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice. Gastroenterology. 142(2):292-304. https://doi.org/10.1053/j.gastro.2011.10.040
• Kunimoto, K., Yamazaki, Y., Nishida, T., Shinohara, K., Ishikawa, H., Hasegawa, T., Okanoue, T., Hamada, H., Noda, T., Tamura, A., Tsukita, S., and ^#Tsukita,S. 2012. Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell. 148(1-2):189-200. https://doi.org/10.1016/j.cell.2011.10.052
• 2011
• Yamazaki, Y., Tokumasu, R., Kimura, H., and ^#Tsukita, S. 2011. Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens. Mol. Biol. Cell. 22(9):1495-504. https://doi.org/10.1091/mbc.E10-12-1003
• Yano, T., Yamazaki, Y., Adachi, M., Okawa, K., Fort, P., Uji, M., Tsukita, S., and ^#Tsukita,S. 2011. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 193(2):319-32. https://doi.org/10.1083/jcb.201009100
• Ibi, M., Zou, P., Inoko, A., Shiromizu, T., Matsuyama, M., Hayashi, Y., Enomoto, M., Mori, D., Hirotsune, S., Kiyono, T., Tsukita, S., Goto, H., and ^#Inagaki, M. 2011. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. J Cell Sci. 124(Pt 6):857-64. https://doi.org/10.1242/jcs.075705
• Koda, R., Zhao, L., Yaoita, E., ^#Yoshida, Y., Tsukita, S., Tamura, A., Nameta, M., Zhang, Y., Fujinaka, H., Magdeldin, S., Xu, B., Narita, I., and Yamamoto, T. 2011. Novel expression of claudin-5 in glomerular podocytes. Cell Tissue Res. 343(3):637-48. https://doi.org/10.1007/s00441-010-1117-y
• Tamura, A., Hayashi, H., Imasato, M., Yamazaki, Y., Hagiwara, A., Wada, M., Noda, T., Watanabe, M., Suzuki, Y., and ^#Tsukita, S. 2011. Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology. 140(3):913-23. https://doi.org/10.1053/j.gastro.2010.08.006
• Mineta, K., Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K., and ^#Tsukita, S. 2011. Predicted expansion of the claudin multigene family. FEBS Lett. 585(4):606-12. https://doi.org/10.1016/j.febslet.2011.01.028